Professor Melita Gordon (MA MD FRCP FHEA) is a clinical scientist with 22 years track-record working on invasive Salmonella disease in Africa and holds a UK National Institutes of Health Research (NIHR) Research Professorship in Global Health, at the University of Liverpool.
She described a high mortality and high rate of recrudescence of iNTS in individuals co-infected with HIV, and demonstrated that this was due to recrudescence of identical strains, and that there was an intracellular element of the infection in both blood and bone marrow, with dysregulated cellular and systemic cytokine milieu, and down-regulated pro-inflammatory responses shown at cellular, molecular and transcriptomic levels. She has also worked on the human gut mucosal cellular response to Salmonella vaccination and infection, demonstrating early systemic and gut mucosal CD4 and CD8 cellular and humoral responses to Salmonella, and additional evidence of systemic trained immunity and heterogeneous immune responses.
In parallel, she has investigated the clinical and phylo-genomic epidemiology of iNTS strains, demonstrating the emergence of 3 sequential epidemics of different serovars of invasive Salmonella disease in Blantyre, associated with multidrug antimicrobial resistance, and with the emergence of novel Salmonella pathovars, demonstrating elements of genomic degradation, pseudogene formation, and critical single SNP changes.
Professor Gordon has been awarded the Blacklock medal of the Liverpool School of Tropical Medicine (1993), the Sir Francis Avery Jones research medal of the British Society of Gastroenterology (2011), and the SAGE first prize for Excellence in Gastroenterology (2012). She is resident full-time at the Malawi-Liverpool-Wellcome Clinical Research Programme in Malawi, leading a research group addressing the epidemiology, genomics, diagnostics, transmission, antimicrobial resistance and vaccinology of typhoid and non-typhoidal invasive Salmonella disease, and training local and international scientists and clinicians.